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Changelog

Source: NEWS.md

ukbrapR v0.2.8 (05 October 2024)

Bug fixes

  • Baseline dates TSV is now correctly located even if user changes working directory
  • HES operations dates were sometimes parsed as character - this is now fixed to parse as dates

Updates

  • Warnings relating to parsing issues during grepping that are safe to ignore are now suppressed
  • Updates to documentation / examples / pkgdown site
  • New website articles to ascertain_diagnoses, label_fields and for spark_functions

ukbrapR v0.2.7 (30 September 2024)

Updates

  • New function label_ukb_field() allows user to add titles and labels to UK Biobank fields provided as integers but are categorical.
  • New function label_ukb_fields() is a wrapper for the above. User just provides a data frame containing UK Biobank fields, and they all get formatted with titles (and labels if categorical).
  • Data from the UK Biobank schema (https://biobank.ctsu.ox.ac.uk/crystal/schema.cgi) are stored internally in ukbrapR:::ukb_schema
  • {haven} dependency added for labelling
  • Exported baseline_dates.tsv now also includes the assessment centres for completeness (but keeps the same filename to avoid any issues for current projects relying on already-exported files)

ukbrapR v0.2.6 (16 September 2024)

Bug fix

  • Fix for issue #10. Grep issues if user provided only Read2 or CTV3 codes, if Read2 or CTV3 were <5 characters, or if Read2/CTV3 codes contained a hyphen. Thanks to @Simon-Leyss for highlighting.
  • Fix for issue #11. When getting self-reported illness codes there was a problem joining the tables if user only provided cancer codes. Thanks to @LauricF for highlighting.
  • Fix for when both types self-reported illness codes were provided. (Incorrect subsetting to just those codes provided after pivoting the long object.)

ukbrapR v0.2.5 (07 September 2024)

Bug fix

  • When getting the date first cancer registry diagnosis, some rows were duplicated. This is now fixed so only one row per participant (the date first for any matched cancer ICD10) is returned.

ukbrapR v0.2.4 (05 September 2024)

Changes

  • Updated internal paths for my servers indy and snow (for ongoing projects whilst we can still use local files…)
  • Updated how get_diagnoses() and get_df() handle a user-provided file_paths object

ukbrapR v0.2.3 (22 August 2024)

Bug fixes

  • Fix for issue #8. In moving the HES ICD10 code block below the cancer registry code I acctidently put it within the if (get_canreg) { } condition. Thanks to @LauricF for highlighting.
  • Fix bullet points in pkgdown version of docs

ukbrapR v0.2.2 (21 August 2024)

Update

  • The HESIN diagnosis search can now also include ICD9 codes in the provided codes data frame. These use fuzzy matching (similar to the ICD10s) so that searching for “280” also returns “2809” etc

ukbrapR v0.2.1 (10 August 2024)

Bug fix

  • Fix for issue #5. The file paths for exported tables were not correctly specified in later calls of get_diagnoses() when the working directory is not the home directory. Thanks to @LauricF for highlighting.

ukbrapR v0.2.0 (30 July 2024)

This is a major update as I move away from using Spark as the default environment, mostly due to the cost implications; it is significantly cheaper (and quicker!) to store and search exported raw text files in the RAP persistant storage than do everything in a Spark environment (plus the added benefit that the RStudio interface is available in “normal” instances).

The Spark functions are available as before but all updates are to improve functionality in “normal” instances using RStudio, as we move to the new era of RAP-only UK Biobank analysis.

Changes

  • Added internal data frame containing default paths for exported files in a RAP project (view with ukbrapR:::ukbrapr_paths)
  • Added function export_tables() which only needs to be run once when a new project is created. This submits the required table exporter commands to extract each of the tables in ukbrapR:::ukbrapr_paths. This can take ~15 minutes to export all the tables. ~10Gb of text files are created. This will cost ~£0.15 per month to store in the RAP standard storage.
  • get_emr() is split into two primary underlying functions: get_emr_spark() which has not changed, and get_emr() which is the “new way” (i.e., get_emr_local() is entirely removed)
  • Added functionality for hesin_oper (HES OPCS operations) searching for ICD10 codes in get_emr()
  • New/updated internal functions get_cancer_registry() asceratains cases using ICD10s in the cancer_registry data, and works much the same as get_selfrep_illness()
  • New function get_diagnoses() is a wrapper to get HES diagnosis, operations, cause of death, GP, cancer registry, and self-reported illness data – i.e., once function to provide all codes to, and return all health-related data
  • get_df() takes all output from get_diagnoses() i.e., now also identifies date of first in matched cancer_registry and hesin_oper entries, in addition to hes_diag, gp_clinical, death_cause and selfrep_illness as before.
  • When getting “date first” using get_df() the baseline data is used to create binary case/control variables (for ever and prevalent), and for controls the censoring date is included in the overall _df variable (default is 30-10-2022).

To make it absolutely clear: the Spark function get_emr_spark() has not been updated but I am no longer focussed on doing things this way. If you want to submit Pull Requests to improve functions please do. The below changes are to substantially improve the experience of using exported tables in the RAP environment only (if you have all the data on a local system already it will work, assuming you format correctly and provide the paths, but the RAP is the future).

ukbrapR v0.1.7 (28 July 2024)

Bug fixes

  • Fix Spark database error when >1 dataset file is available. Fixes issue #3

ukbrapR v0.1.6 (03 July 2024)

Bug fixes

  • Fix get_df() error when ascertaining GP diagnoses if 7-character codes were provided rather than 5

Changes

  • get_emr() now accepts option “file_paths” - if not provided, attempts to get from Spark
  • Improve documentation and examples

ukbrapR v0.1.5 (01 July 2024)

Bug fixes

  • Fix get_df() error occurring when not all sources are desired

Changes

  • get_emr_local() option “local_paths” is now “file_paths”
  • Improve documentation and examples

ukbrapR v0.1.4 (12 June 2024)

Bug fixes

  • Fix problem identifying ICD10 column name in RAP HESIN
  • Fix problem getting date first for GP data (excluding missing dates before summarizing)

ukbrapR v0.1.3 (8 June 2024)

New feature

  • It is quicker/easier to ascertain multiple conditions at once to supply get_emr() with all the codes (as before), but now can use get_df() with option “group_by” to indicate the condition names in the codes_df object provided. See documentation.

Changes

  • It is no longer possible to provide custom names for the codes_df to get_emr() – these now must be vocab_id and code – makes things much simpler.
  • Remove ICD9 code from codes_df_hh example as these are not currently used

ukbrapR v0.1.2 (6 June 2024)

New features

  • New function get_emr_local(). If the user has text files for hesin_diag and gp_clinical etc. these can be searched (rather than Apache Spark queries). This therefore can work on “normal” DNAnexus nodes, or local servers. Most downstream functions also do not rely on Spark clusters if data extracts are available.

Changes

ukbrapR v0.1.1 (6 March 2024)

New features

  • New argument “prefix” for get_df() - user can provide a string to prefix to the output variable names

ukbrapR v0.1.0 (21 Feb 2024)

New features

  • get_selfrep_illness() - gets illness information from self-report fields. Derives a “date first” from the age/year reported, incorporating all visits for the participant
  • Two example code lists are incuded: codes_df_ckd (GEMINI CKD), and codes_df_hh (haemochromatosis, with self-report)

Changes

  • get_emr_df() is re-named get_df() to reflect it can now include information from self-reported illness
  • get_emr_diagnoses() is re-named get_emr() to reflect it actually retrieves any record in gp_clinical not just diagnoses (e.g., BMI if appropriate codes provided)

Bug fixes

  • So many

ukbrapR v0.0.2 (14 Nov 2023)

New features

  • get_emr_diagnoses() - function to get electronic medical records diagnoses from Spark-based death records, hospital episode statistics, and primary care (GP) databases.
  • get_emr_df() - function to get date first diagnosed with any provided code from any above Electronic Medical Record source.

Bug fixes

  • Extra input checking in get_rap_phenos() and output more consistent for direct use with get_emr_*() functions
  • Updated URL for example CKD clinical codes

ukbrapR v0.0.1 (26 Oct 2023)

Initial release containing two functions: - get_rap_phenos() - upload_to_rap()